Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.
Identifieur interne : 001163 ( Main/Exploration ); précédent : 001162; suivant : 001164Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.
Auteurs : Shona Hendry [États-Unis] ; Roberto Salgado ; Thomas Gevaert ; Prudence A. Russell ; Tom John ; Bibhusal Thapa ; Michael Christie ; Koen Van De Vijver ; M V Estrada ; Paula I. Gonzalez-Ericsson ; Melinda Sanders ; Benjamin Solomon ; Cinzia Solinas ; Gert G G M. Van Den Eynden ; Yves Allory ; Matthias Preusser ; Johannes Hainfellner ; Giancarlo Pruneri ; Andrea Vingiani ; Sandra Demaria ; Fraser Symmans ; Paolo Nuciforo ; Laura Comerma ; E A Thompson ; Sunil Lakhani ; Seong-Rim Kim ; Stuart Schnitt ; Cecile Colpaert ; Christos Sotiriou ; Stefan J. Scherer ; Michail Ignatiadis ; Sunil Badve ; Robert H. Pierce ; Giuseppe Viale ; Nicolas Sirtaine ; Frederique Penault-Llorca ; Tomohagu Sugie ; Susan Fineberg ; Soonmyung Paik ; Ashok Srinivasan ; Andrea Richardson ; Yihong Wang ; Ewa Chmielik ; Jane Brock ; Douglas B. Johnson ; Justin Balko ; Stephan Wienert ; Veerle Bossuyt ; Stefan Michiels ; Nils Ternes ; Nicole Burchardi ; Stephen J. Luen ; Peter Savas ; Frederick Klauschen ; Peter H. Watson ; Brad H. Nelson ; Carmen Criscitiello ; Sandra O'Toole ; Denis Larsimont ; Roland De Wind ; Giuseppe Curigliano ; Fabrice André ; Magali Lacroix-Triki ; Mark Van De Vijver ; Federico Rojo ; Giuseppe Floris ; Shahinaz Bedri ; Joseph Sparano ; David Rimm ; Torsten Nielsen ; Zuzana Kos ; Stephen Hewitt ; Baljit Singh ; Gelareh Farshid ; Sibylle Loibl ; Kimberly H. Allison ; Nadine Tung ; Sylvia Adams ; Karen Willard-Gallo ; Hugo M. Horlings ; Leena Gandhi ; Andre Moreira ; Fred Hirsch ; Maria V. Dieci ; Maria Urbanowicz ; Iva Brcic ; Konstanty Korski ; Fabien Gaire ; Hartmut Koeppen ; Amy Lo ; Jennifer Giltnane ; Marlon C. Rebelatto ; Keith E. Steele ; Jiping Zha ; Kenneth Emancipator ; Jonathan W. Juco ; Carsten Denkert ; Jorge Reis-Filho ; Sherene Loi ; Stephen B. FoxSource :
- Advances in anatomic pathology [ 1533-4031 ] ; 2017.
Abstract
Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.
DOI: 10.1097/PAP.0000000000000162
PubMed: 28777142
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.</title><author><name sortKey="Hendry, Shona" sort="Hendry, Shona" uniqKey="Hendry S" first="Shona" last="Hendry">Shona Hendry</name><affiliation wicri:level="2"><nlm:affiliation>Departments of *Pathology §§§Medical Oncology, Peter MacCallum Cancer Centre, Melbourne †The Sir Peter MacCallum Department of Oncology Departments of **Pathology ∥∥Medicine, University of Melbourne ¶¶Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville #Department of Anatomical Pathology, St Vincent's Hospital Melbourne, Fitzroy ††Department of Medical Oncology, Austin Health ‡‡Olivia Newton-John Cancer Research Institute, Heidelberg §§School of Cancer Medicine, La Trobe University, Bundoora §§§§§Centre for Clinical Research and School of Medicine, The University of Queensland ∥∥∥∥∥Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane §§§§§§§§§§The Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst ∥∥∥∥∥∥∥∥∥∥Australian Clinical Labs, Bella Vista ‡‡‡‡‡‡‡‡‡‡‡‡Directorate of Surgical Pathology, SA Pathology §§§§§§§§§§§§Discipline of Medicine, Adelaide University, Adelaide, Australia ***********Department of Surgical Oncology, Netherlands Cancer Institute †††††††††††††Department of Pathology ##Divisions of Diagnostic Oncology & Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands ###Université Paris-Est ****INSERM, UMR 955 ††††Département de pathologie, APHP, Hôpital Henri-Mondor, Créteil ∥∥∥∥∥∥∥∥∥Service de Biostatistique et d'Epidémiologie, Gustave Roussy, CESP, Inserm U1018, Université-Paris Sud, Université Paris-Saclay ¶¶¶¶¶¶¶¶¶¶INSERM Unit U981, and Department of Medical Oncology, Gustave Roussy, Villejuif ##########Faculté de Médecine, Université Paris Sud, Kremlin-Bicêtre †††††††Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre ‡‡‡‡‡‡‡University of Auvergne UMR1240, Clermont-Ferrand, France ‡‡‡‡Department of Medicine, Clinical Division of Oncology §§§§Institute of Neurology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Vienna ††††††††††††††Institute of Pathology, Medical University of Graz, Austria ∥∥∥∥European Institute of Oncology ¶¶¶¶School of Medicine ######Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan ¶¶¶¶¶¶¶¶¶¶¶¶¶Department of Surgery, Oncology and Gastroenterology, University of Padova #############Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy †††††Molecular Oncology Group, Vall d'Hebron Institute of Oncology, Barcelona †††††††††††Pathology Department, IIS-Fundacion Jimenez Diaz, UAM, Madrid, Spain §Department of Pathology and TCRU, GZA ¶¶¶Department of Pathology, GZA Ziekenhuizen, Antwerp ∥Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven ‡‡‡‡‡‡‡‡‡‡‡Department of Pathology, University Hospital Leuven, Leuven, Belgium ¶Department of Pathology, AZ Klina, Brasschaat ††††††Department of Pathology, GZA Ziekenhuizen, Sint-Augustinus, Wilrijk ∥∥∥Molecular Immunology Unit ‡‡‡‡‡‡Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles ‡Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet **************European Organisation for Research and Treatment of Cancer (EORTC) Headquarters *******Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium §§§§§§§Department of Surgery, Kansai Medical School, Hirakata, Japan #######Severance Biomedical Science Institute and Department of Medical Oncology, Yonsei University College of Medicine, Seoul, South Korea ∥∥∥∥∥∥∥∥Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center ¶¶¶¶¶¶¶¶Institute of Oncology, Gliwice Branch, Gliwice, Poland ‡‡‡‡‡‡‡‡‡‡‡‡‡‡Pathology and Tissue Analytics, Roche Innovation Centre Munich, Penzberg †††††††††Institute of Pathology, Charité Universitätsmedizin Berlin ‡‡‡‡‡‡‡‡‡VMscope GmbH, Berlin ¶¶¶¶¶¶¶¶¶German Breast Group GmbH, Neu-Isenburg, Germany **********Trev & Joyce Deeley Research Centre, British Columbia Cancer Agency ††††††††††Department of Biochemistry and Microbiology, University of Victoria, Victoria Departments of ‡‡‡‡‡‡‡‡‡‡Medical Genetics #########Pathology and Laboratory Medicine ¶¶¶¶¶¶¶¶¶¶¶Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC ###########Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada §§§§§§§§§§§Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Doha, Qatar ‡‡‡‡‡‡‡‡Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center §§§§§§§§Warren Alpert Medical School of Brown University, Providence ¶¶¶¶¶National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, PA †††Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Departments of ‡‡‡Pathology, Microbiology and Immunology ########Department of Medicine, Vanderbilt University Medical Centre *********Vanderbilt Ingram Cancer Center, Nashville §§§§§§§§§Department of Pathology, Yale University School of Medicine, New Haven ∥∥∥∥∥∥∥∥∥∥∥Department of Oncology, Montefiore Medical Centre, Albert Einstein College of Medicine ∥∥∥∥∥∥∥Montefiore Medical Center ¶¶¶¶¶¶¶The Albert Einstein College of Medicine, Bronx, NY ********Department of Pathology, Brigham and Women's Hospital #####Cancer Research Institute and Department of Pathology, Beth Israel Deaconess Cancer Center ******Harvard Medical School ¶¶¶¶¶¶¶¶¶¶¶¶Division of Hematology-Oncology, Beth Israel Deaconess Medical Center ††††††††Department of Cancer Biology ‡‡‡‡‡‡‡‡‡‡‡‡‡Dana-Farber Cancer Institute, Boston, MA ∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO ‡‡‡‡‡Department of Cancer Biology, Mayo Clinic, Jacksonville, FL ∥∥∥∥∥∥Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN ¶¶¶¶¶¶Cancer Immunotherapy Trials Network, Central Laboratory and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA ††††††††††††Department of Pathology, New York University Langone Medical Centre ############New York University Medical School *************Perlmutter Cancer Center §§§§§§§§§§§§§Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University ***************Department of Pathology, Memorial Sloan-Kettering Cancer Center ####Departments of Radiation Oncology and Pathology, Weill Cornell Medicine, New York, NY *****Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX ∥∥∥∥∥∥∥∥∥∥∥∥Pathology Department, Stanford University Medical Centre, Stanford ∥∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Pathology, Stanford University, Palo Alto ***Department of Pathology, School of Medicine, University of California, San Diego §§§§§§§§§§§§§§Research Pathology, Genentech Inc., South San Francisco, CA *************Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda ¶¶¶¶¶¶¶¶¶¶¶¶¶¶Translational Sciences, MedImmune, Gaithersberg, MD §§§§§§Academic Medical Innovation, Novartis Pharmaceuticals Corporation, East Hanover ##############Translational Medicine, Merck & Co. Inc., Kenilworth, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Departments of *Pathology §§§Medical Oncology, Peter MacCallum Cancer Centre, Melbourne †The Sir Peter MacCallum Department of Oncology Departments of **Pathology ∥∥Medicine, University of Melbourne ¶¶Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville #Department of Anatomical Pathology, St Vincent's Hospital Melbourne, Fitzroy ††Department of Medical Oncology, Austin Health ‡‡Olivia Newton-John Cancer Research Institute, Heidelberg §§School of Cancer Medicine, La Trobe University, Bundoora §§§§§Centre for Clinical Research and School of Medicine, The University of Queensland ∥∥∥∥∥Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane §§§§§§§§§§The Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst ∥∥∥∥∥∥∥∥∥∥Australian Clinical Labs, Bella Vista ‡‡‡‡‡‡‡‡‡‡‡‡Directorate of Surgical Pathology, SA Pathology §§§§§§§§§§§§Discipline of Medicine, Adelaide University, Adelaide, Australia ***********Department of Surgical Oncology, Netherlands Cancer Institute †††††††††††††Department of Pathology ##Divisions of Diagnostic Oncology & Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands ###Université Paris-Est ****INSERM, UMR 955 ††††Département de pathologie, APHP, Hôpital Henri-Mondor, Créteil ∥∥∥∥∥∥∥∥∥Service de Biostatistique et d'Epidémiologie, Gustave Roussy, CESP, Inserm U1018, Université-Paris Sud, Université Paris-Saclay ¶¶¶¶¶¶¶¶¶¶INSERM Unit U981, and Department of Medical Oncology, Gustave Roussy, Villejuif ##########Faculté de Médecine, Université Paris Sud, Kremlin-Bicêtre †††††††Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre ‡‡‡‡‡‡‡University of Auvergne UMR1240, Clermont-Ferrand, France ‡‡‡‡Department of Medicine, Clinical Division of Oncology §§§§Institute of Neurology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Vienna ††††††††††††††Institute of Pathology, Medical University of Graz, Austria ∥∥∥∥European Institute of Oncology ¶¶¶¶School of Medicine ######Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan ¶¶¶¶¶¶¶¶¶¶¶¶¶Department of Surgery, Oncology and Gastroenterology, University of Padova #############Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy †††††Molecular Oncology Group, Vall d'Hebron Institute of Oncology, Barcelona †††††††††††Pathology Department, IIS-Fundacion Jimenez Diaz, UAM, Madrid, Spain §Department of Pathology and TCRU, GZA ¶¶¶Department of Pathology, GZA Ziekenhuizen, Antwerp ∥Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven ‡‡‡‡‡‡‡‡‡‡‡Department of Pathology, University Hospital Leuven, Leuven, Belgium ¶Department of Pathology, AZ Klina, Brasschaat ††††††Department of Pathology, GZA Ziekenhuizen, Sint-Augustinus, Wilrijk ∥∥∥Molecular Immunology Unit ‡‡‡‡‡‡Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles ‡Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet **************European Organisation for Research and Treatment of Cancer (EORTC) Headquarters *******Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium §§§§§§§Department of Surgery, Kansai Medical School, Hirakata, Japan #######Severance Biomedical Science Institute and Department of Medical Oncology, Yonsei University College of Medicine, Seoul, South Korea ∥∥∥∥∥∥∥∥Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center ¶¶¶¶¶¶¶¶Institute of Oncology, Gliwice Branch, Gliwice, Poland ‡‡‡‡‡‡‡‡‡‡‡‡‡‡Pathology and Tissue Analytics, Roche Innovation Centre Munich, Penzberg †††††††††Institute of Pathology, Charité Universitätsmedizin Berlin ‡‡‡‡‡‡‡‡‡VMscope GmbH, Berlin ¶¶¶¶¶¶¶¶¶German Breast Group GmbH, Neu-Isenburg, Germany **********Trev & Joyce Deeley Research Centre, British Columbia Cancer Agency ††††††††††Department of Biochemistry and Microbiology, University of Victoria, Victoria Departments of ‡‡‡‡‡‡‡‡‡‡Medical Genetics #########Pathology and Laboratory Medicine ¶¶¶¶¶¶¶¶¶¶¶Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC ###########Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada §§§§§§§§§§§Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Doha, Qatar ‡‡‡‡‡‡‡‡Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center §§§§§§§§Warren Alpert Medical School of Brown University, Providence ¶¶¶¶¶National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, PA †††Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Departments of ‡‡‡Pathology, Microbiology and Immunology ########Department of Medicine, Vanderbilt University Medical Centre *********Vanderbilt Ingram Cancer Center, Nashville §§§§§§§§§Department of Pathology, Yale University School of Medicine, New Haven ∥∥∥∥∥∥∥∥∥∥∥Department of Oncology, Montefiore Medical Centre, Albert Einstein College of Medicine ∥∥∥∥∥∥∥Montefiore Medical Center ¶¶¶¶¶¶¶The Albert Einstein College of Medicine, Bronx, NY ********Department of Pathology, Brigham and Women's Hospital #####Cancer Research Institute and Department of Pathology, Beth Israel Deaconess Cancer Center ******Harvard Medical School ¶¶¶¶¶¶¶¶¶¶¶¶Division of Hematology-Oncology, Beth Israel Deaconess Medical Center ††††††††Department of Cancer Biology ‡‡‡‡‡‡‡‡‡‡‡‡‡Dana-Farber Cancer Institute, Boston, MA ∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO ‡‡‡‡‡Department of Cancer Biology, Mayo Clinic, Jacksonville, FL ∥∥∥∥∥∥Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN ¶¶¶¶¶¶Cancer Immunotherapy Trials Network, Central Laboratory and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA ††††††††††††Department of Pathology, New York University Langone Medical Centre ############New York University Medical School *************Perlmutter Cancer Center §§§§§§§§§§§§§Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University ***************Department of Pathology, Memorial Sloan-Kettering Cancer Center ####Departments of Radiation Oncology and Pathology, Weill Cornell Medicine, New York, NY *****Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX ∥∥∥∥∥∥∥∥∥∥∥∥Pathology Department, Stanford University Medical Centre, Stanford ∥∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Pathology, Stanford University, Palo Alto ***Department of Pathology, School of Medicine, University of California, San Diego §§§§§§§§§§§§§§Research Pathology, Genentech Inc., South San Francisco, CA *************Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda ¶¶¶¶¶¶¶¶¶¶¶¶¶¶Translational Sciences, MedImmune, Gaithersberg, MD §§§§§§Academic Medical Innovation, Novartis Pharmaceuticals Corporation, East Hanover ##############Translational Medicine, Merck & Co. Inc., Kenilworth</wicri:cityArea></affiliation></author><author><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name></author><author><name sortKey="Gevaert, Thomas" sort="Gevaert, Thomas" uniqKey="Gevaert T" first="Thomas" last="Gevaert">Thomas Gevaert</name></author><author><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name></author><author><name sortKey="John, Tom" sort="John, Tom" uniqKey="John T" first="Tom" last="John">Tom John</name></author><author><name sortKey="Thapa, Bibhusal" sort="Thapa, Bibhusal" uniqKey="Thapa B" first="Bibhusal" last="Thapa">Bibhusal Thapa</name></author><author><name sortKey="Christie, Michael" sort="Christie, Michael" uniqKey="Christie M" first="Michael" last="Christie">Michael Christie</name></author><author><name sortKey="Van De Vijver, Koen" sort="Van De Vijver, Koen" uniqKey="Van De Vijver K" first="Koen" last="Van De Vijver">Koen Van De Vijver</name></author><author><name sortKey="Estrada, M V" sort="Estrada, M V" uniqKey="Estrada M" first="M V" last="Estrada">M V Estrada</name></author><author><name sortKey="Gonzalez Ericsson, Paula I" sort="Gonzalez Ericsson, Paula I" uniqKey="Gonzalez Ericsson P" first="Paula I" last="Gonzalez-Ericsson">Paula I. Gonzalez-Ericsson</name></author><author><name sortKey="Sanders, Melinda" sort="Sanders, Melinda" uniqKey="Sanders M" first="Melinda" last="Sanders">Melinda Sanders</name></author><author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name></author><author><name sortKey="Solinas, Cinzia" sort="Solinas, Cinzia" uniqKey="Solinas C" first="Cinzia" last="Solinas">Cinzia Solinas</name></author><author><name sortKey="Van Den Eynden, Gert G G M" sort="Van Den Eynden, Gert G G M" uniqKey="Van Den Eynden G" first="Gert G G M" last="Van Den Eynden">Gert G G M. Van Den Eynden</name></author><author><name sortKey="Allory, Yves" sort="Allory, Yves" uniqKey="Allory Y" first="Yves" last="Allory">Yves Allory</name></author><author><name sortKey="Preusser, Matthias" sort="Preusser, Matthias" uniqKey="Preusser M" first="Matthias" last="Preusser">Matthias Preusser</name></author><author><name sortKey="Hainfellner, Johannes" sort="Hainfellner, Johannes" uniqKey="Hainfellner J" first="Johannes" last="Hainfellner">Johannes Hainfellner</name></author><author><name sortKey="Pruneri, Giancarlo" sort="Pruneri, Giancarlo" uniqKey="Pruneri G" first="Giancarlo" last="Pruneri">Giancarlo Pruneri</name></author><author><name sortKey="Vingiani, Andrea" sort="Vingiani, Andrea" uniqKey="Vingiani A" first="Andrea" last="Vingiani">Andrea Vingiani</name></author><author><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name></author><author><name sortKey="Symmans, Fraser" sort="Symmans, Fraser" uniqKey="Symmans F" first="Fraser" last="Symmans">Fraser Symmans</name></author><author><name sortKey="Nuciforo, Paolo" sort="Nuciforo, Paolo" uniqKey="Nuciforo P" first="Paolo" last="Nuciforo">Paolo Nuciforo</name></author><author><name sortKey="Comerma, Laura" sort="Comerma, Laura" uniqKey="Comerma L" first="Laura" last="Comerma">Laura Comerma</name></author><author><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name></author><author><name sortKey="Lakhani, Sunil" sort="Lakhani, Sunil" uniqKey="Lakhani S" first="Sunil" last="Lakhani">Sunil Lakhani</name></author><author><name sortKey="Kim, Seong Rim" sort="Kim, Seong Rim" uniqKey="Kim S" first="Seong-Rim" last="Kim">Seong-Rim Kim</name></author><author><name sortKey="Schnitt, Stuart" sort="Schnitt, Stuart" uniqKey="Schnitt S" first="Stuart" last="Schnitt">Stuart Schnitt</name></author><author><name sortKey="Colpaert, Cecile" sort="Colpaert, Cecile" uniqKey="Colpaert C" first="Cecile" last="Colpaert">Cecile Colpaert</name></author><author><name sortKey="Sotiriou, Christos" sort="Sotiriou, Christos" uniqKey="Sotiriou C" first="Christos" last="Sotiriou">Christos Sotiriou</name></author><author><name sortKey="Scherer, Stefan J" sort="Scherer, Stefan J" uniqKey="Scherer S" first="Stefan J" last="Scherer">Stefan J. Scherer</name></author><author><name sortKey="Ignatiadis, Michail" sort="Ignatiadis, Michail" uniqKey="Ignatiadis M" first="Michail" last="Ignatiadis">Michail Ignatiadis</name></author><author><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name></author><author><name sortKey="Pierce, Robert H" sort="Pierce, Robert H" uniqKey="Pierce R" first="Robert H" last="Pierce">Robert H. Pierce</name></author><author><name sortKey="Viale, Giuseppe" sort="Viale, Giuseppe" uniqKey="Viale G" first="Giuseppe" last="Viale">Giuseppe Viale</name></author><author><name sortKey="Sirtaine, Nicolas" sort="Sirtaine, Nicolas" uniqKey="Sirtaine N" first="Nicolas" last="Sirtaine">Nicolas Sirtaine</name></author><author><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name></author><author><name sortKey="Sugie, Tomohagu" sort="Sugie, Tomohagu" uniqKey="Sugie T" first="Tomohagu" last="Sugie">Tomohagu Sugie</name></author><author><name sortKey="Fineberg, Susan" sort="Fineberg, Susan" uniqKey="Fineberg S" first="Susan" last="Fineberg">Susan Fineberg</name></author><author><name sortKey="Paik, Soonmyung" sort="Paik, Soonmyung" uniqKey="Paik S" first="Soonmyung" last="Paik">Soonmyung Paik</name></author><author><name sortKey="Srinivasan, Ashok" sort="Srinivasan, Ashok" uniqKey="Srinivasan A" first="Ashok" last="Srinivasan">Ashok Srinivasan</name></author><author><name sortKey="Richardson, Andrea" sort="Richardson, Andrea" uniqKey="Richardson A" first="Andrea" last="Richardson">Andrea Richardson</name></author><author><name sortKey="Wang, Yihong" sort="Wang, Yihong" uniqKey="Wang Y" first="Yihong" last="Wang">Yihong Wang</name></author><author><name sortKey="Chmielik, Ewa" sort="Chmielik, Ewa" uniqKey="Chmielik E" first="Ewa" last="Chmielik">Ewa Chmielik</name></author><author><name sortKey="Brock, Jane" sort="Brock, Jane" uniqKey="Brock J" first="Jane" last="Brock">Jane Brock</name></author><author><name sortKey="Johnson, Douglas B" sort="Johnson, Douglas B" uniqKey="Johnson D" first="Douglas B" last="Johnson">Douglas B. Johnson</name></author><author><name sortKey="Balko, Justin" sort="Balko, Justin" uniqKey="Balko J" first="Justin" last="Balko">Justin Balko</name></author><author><name sortKey="Wienert, Stephan" sort="Wienert, Stephan" uniqKey="Wienert S" first="Stephan" last="Wienert">Stephan Wienert</name></author><author><name sortKey="Bossuyt, Veerle" sort="Bossuyt, Veerle" uniqKey="Bossuyt V" first="Veerle" last="Bossuyt">Veerle Bossuyt</name></author><author><name sortKey="Michiels, Stefan" sort="Michiels, Stefan" uniqKey="Michiels S" first="Stefan" last="Michiels">Stefan Michiels</name></author><author><name sortKey="Ternes, Nils" sort="Ternes, Nils" uniqKey="Ternes N" first="Nils" last="Ternes">Nils Ternes</name></author><author><name sortKey="Burchardi, Nicole" sort="Burchardi, Nicole" uniqKey="Burchardi N" first="Nicole" last="Burchardi">Nicole Burchardi</name></author><author><name sortKey="Luen, Stephen J" sort="Luen, Stephen J" uniqKey="Luen S" first="Stephen J" last="Luen">Stephen J. Luen</name></author><author><name sortKey="Savas, Peter" sort="Savas, Peter" uniqKey="Savas P" first="Peter" last="Savas">Peter Savas</name></author><author><name sortKey="Klauschen, Frederick" sort="Klauschen, Frederick" uniqKey="Klauschen F" first="Frederick" last="Klauschen">Frederick Klauschen</name></author><author><name sortKey="Watson, Peter H" sort="Watson, Peter H" uniqKey="Watson P" first="Peter H" last="Watson">Peter H. Watson</name></author><author><name sortKey="Nelson, Brad H" sort="Nelson, Brad H" uniqKey="Nelson B" first="Brad H" last="Nelson">Brad H. Nelson</name></author><author><name sortKey="Criscitiello, Carmen" sort="Criscitiello, Carmen" uniqKey="Criscitiello C" first="Carmen" last="Criscitiello">Carmen Criscitiello</name></author><author><name sortKey="O Toole, Sandra" sort="O Toole, Sandra" uniqKey="O Toole S" first="Sandra" last="O'Toole">Sandra O'Toole</name></author><author><name sortKey="Larsimont, Denis" sort="Larsimont, Denis" uniqKey="Larsimont D" first="Denis" last="Larsimont">Denis Larsimont</name></author><author><name sortKey="De Wind, Roland" sort="De Wind, Roland" uniqKey="De Wind R" first="Roland" last="De Wind">Roland De Wind</name></author><author><name sortKey="Curigliano, Giuseppe" sort="Curigliano, Giuseppe" uniqKey="Curigliano G" first="Giuseppe" last="Curigliano">Giuseppe Curigliano</name></author><author><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="André">Fabrice André</name></author><author><name sortKey="Lacroix Triki, Magali" sort="Lacroix Triki, Magali" uniqKey="Lacroix Triki M" first="Magali" last="Lacroix-Triki">Magali Lacroix-Triki</name></author><author><name sortKey="Van De Vijver, Mark" sort="Van De Vijver, Mark" uniqKey="Van De Vijver M" first="Mark" last="Van De Vijver">Mark Van De Vijver</name></author><author><name sortKey="Rojo, Federico" sort="Rojo, Federico" uniqKey="Rojo F" first="Federico" last="Rojo">Federico Rojo</name></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name></author><author><name sortKey="Bedri, Shahinaz" sort="Bedri, Shahinaz" uniqKey="Bedri S" first="Shahinaz" last="Bedri">Shahinaz Bedri</name></author><author><name sortKey="Sparano, Joseph" sort="Sparano, Joseph" uniqKey="Sparano J" first="Joseph" last="Sparano">Joseph Sparano</name></author><author><name sortKey="Rimm, David" sort="Rimm, David" uniqKey="Rimm D" first="David" last="Rimm">David Rimm</name></author><author><name sortKey="Nielsen, Torsten" sort="Nielsen, Torsten" uniqKey="Nielsen T" first="Torsten" last="Nielsen">Torsten Nielsen</name></author><author><name sortKey="Kos, Zuzana" sort="Kos, Zuzana" uniqKey="Kos Z" first="Zuzana" last="Kos">Zuzana Kos</name></author><author><name sortKey="Hewitt, Stephen" sort="Hewitt, Stephen" uniqKey="Hewitt S" first="Stephen" last="Hewitt">Stephen Hewitt</name></author><author><name sortKey="Singh, Baljit" sort="Singh, Baljit" uniqKey="Singh B" first="Baljit" last="Singh">Baljit Singh</name></author><author><name sortKey="Farshid, Gelareh" sort="Farshid, Gelareh" uniqKey="Farshid G" first="Gelareh" last="Farshid">Gelareh Farshid</name></author><author><name sortKey="Loibl, Sibylle" sort="Loibl, Sibylle" uniqKey="Loibl S" first="Sibylle" last="Loibl">Sibylle Loibl</name></author><author><name sortKey="Allison, Kimberly H" sort="Allison, Kimberly H" uniqKey="Allison K" first="Kimberly H" last="Allison">Kimberly H. Allison</name></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name></author><author><name sortKey="Adams, Sylvia" sort="Adams, Sylvia" uniqKey="Adams S" first="Sylvia" last="Adams">Sylvia Adams</name></author><author><name sortKey="Willard Gallo, Karen" sort="Willard Gallo, Karen" uniqKey="Willard Gallo K" first="Karen" last="Willard-Gallo">Karen Willard-Gallo</name></author><author><name sortKey="Horlings, Hugo M" sort="Horlings, Hugo M" uniqKey="Horlings H" first="Hugo M" last="Horlings">Hugo M. Horlings</name></author><author><name sortKey="Gandhi, Leena" sort="Gandhi, Leena" uniqKey="Gandhi L" first="Leena" last="Gandhi">Leena Gandhi</name></author><author><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name></author><author><name sortKey="Hirsch, Fred" sort="Hirsch, Fred" uniqKey="Hirsch F" first="Fred" last="Hirsch">Fred Hirsch</name></author><author><name sortKey="Dieci, Maria V" sort="Dieci, Maria V" uniqKey="Dieci M" first="Maria V" last="Dieci">Maria V. Dieci</name></author><author><name sortKey="Urbanowicz, Maria" sort="Urbanowicz, Maria" uniqKey="Urbanowicz M" first="Maria" last="Urbanowicz">Maria Urbanowicz</name></author><author><name sortKey="Brcic, Iva" sort="Brcic, Iva" uniqKey="Brcic I" first="Iva" last="Brcic">Iva Brcic</name></author><author><name sortKey="Korski, Konstanty" sort="Korski, Konstanty" uniqKey="Korski K" first="Konstanty" last="Korski">Konstanty Korski</name></author><author><name sortKey="Gaire, Fabien" sort="Gaire, Fabien" uniqKey="Gaire F" first="Fabien" last="Gaire">Fabien Gaire</name></author><author><name sortKey="Koeppen, Hartmut" sort="Koeppen, Hartmut" uniqKey="Koeppen H" first="Hartmut" last="Koeppen">Hartmut Koeppen</name></author><author><name sortKey="Lo, Amy" sort="Lo, Amy" uniqKey="Lo A" first="Amy" last="Lo">Amy Lo</name></author><author><name sortKey="Giltnane, Jennifer" sort="Giltnane, Jennifer" uniqKey="Giltnane J" first="Jennifer" last="Giltnane">Jennifer Giltnane</name></author><author><name sortKey="Rebelatto, Marlon C" sort="Rebelatto, Marlon C" uniqKey="Rebelatto M" first="Marlon C" last="Rebelatto">Marlon C. Rebelatto</name></author><author><name sortKey="Steele, Keith E" sort="Steele, Keith E" uniqKey="Steele K" first="Keith E" last="Steele">Keith E. Steele</name></author><author><name sortKey="Zha, Jiping" sort="Zha, Jiping" uniqKey="Zha J" first="Jiping" last="Zha">Jiping Zha</name></author><author><name sortKey="Emancipator, Kenneth" sort="Emancipator, Kenneth" uniqKey="Emancipator K" first="Kenneth" last="Emancipator">Kenneth Emancipator</name></author><author><name sortKey="Juco, Jonathan W" sort="Juco, Jonathan W" uniqKey="Juco J" first="Jonathan W" last="Juco">Jonathan W. Juco</name></author><author><name sortKey="Denkert, Carsten" sort="Denkert, Carsten" uniqKey="Denkert C" first="Carsten" last="Denkert">Carsten Denkert</name></author><author><name sortKey="Reis Filho, Jorge" sort="Reis Filho, Jorge" uniqKey="Reis Filho J" first="Jorge" last="Reis-Filho">Jorge Reis-Filho</name></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name></author><author><name sortKey="Fox, Stephen B" sort="Fox, Stephen B" uniqKey="Fox S" first="Stephen B" last="Fox">Stephen B. Fox</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28777142</idno><idno type="pmid">28777142</idno><idno type="doi">10.1097/PAP.0000000000000162</idno><idno type="wicri:Area/PubMed/Corpus">000526</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000526</idno><idno type="wicri:Area/PubMed/Curation">000524</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000524</idno><idno type="wicri:Area/PubMed/Checkpoint">000524</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000524</idno><idno type="wicri:Area/Ncbi/Merge">004C44</idno><idno type="wicri:Area/Ncbi/Curation">004C44</idno><idno type="wicri:Area/Ncbi/Checkpoint">004C44</idno><idno type="wicri:Area/Main/Merge">001158</idno><idno type="wicri:Area/Main/Curation">001163</idno><idno type="wicri:Area/Main/Exploration">001163</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.</title><author><name sortKey="Hendry, Shona" sort="Hendry, Shona" uniqKey="Hendry S" first="Shona" last="Hendry">Shona Hendry</name><affiliation wicri:level="2"><nlm:affiliation>Departments of *Pathology §§§Medical Oncology, Peter MacCallum Cancer Centre, Melbourne †The Sir Peter MacCallum Department of Oncology Departments of **Pathology ∥∥Medicine, University of Melbourne ¶¶Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville #Department of Anatomical Pathology, St Vincent's Hospital Melbourne, Fitzroy ††Department of Medical Oncology, Austin Health ‡‡Olivia Newton-John Cancer Research Institute, Heidelberg §§School of Cancer Medicine, La Trobe University, Bundoora §§§§§Centre for Clinical Research and School of Medicine, The University of Queensland ∥∥∥∥∥Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane §§§§§§§§§§The Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst ∥∥∥∥∥∥∥∥∥∥Australian Clinical Labs, Bella Vista ‡‡‡‡‡‡‡‡‡‡‡‡Directorate of Surgical Pathology, SA Pathology §§§§§§§§§§§§Discipline of Medicine, Adelaide University, Adelaide, Australia ***********Department of Surgical Oncology, Netherlands Cancer Institute †††††††††††††Department of Pathology ##Divisions of Diagnostic Oncology & Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands ###Université Paris-Est ****INSERM, UMR 955 ††††Département de pathologie, APHP, Hôpital Henri-Mondor, Créteil ∥∥∥∥∥∥∥∥∥Service de Biostatistique et d'Epidémiologie, Gustave Roussy, CESP, Inserm U1018, Université-Paris Sud, Université Paris-Saclay ¶¶¶¶¶¶¶¶¶¶INSERM Unit U981, and Department of Medical Oncology, Gustave Roussy, Villejuif ##########Faculté de Médecine, Université Paris Sud, Kremlin-Bicêtre †††††††Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre ‡‡‡‡‡‡‡University of Auvergne UMR1240, Clermont-Ferrand, France ‡‡‡‡Department of Medicine, Clinical Division of Oncology §§§§Institute of Neurology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Vienna ††††††††††††††Institute of Pathology, Medical University of Graz, Austria ∥∥∥∥European Institute of Oncology ¶¶¶¶School of Medicine ######Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan ¶¶¶¶¶¶¶¶¶¶¶¶¶Department of Surgery, Oncology and Gastroenterology, University of Padova #############Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy †††††Molecular Oncology Group, Vall d'Hebron Institute of Oncology, Barcelona †††††††††††Pathology Department, IIS-Fundacion Jimenez Diaz, UAM, Madrid, Spain §Department of Pathology and TCRU, GZA ¶¶¶Department of Pathology, GZA Ziekenhuizen, Antwerp ∥Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven ‡‡‡‡‡‡‡‡‡‡‡Department of Pathology, University Hospital Leuven, Leuven, Belgium ¶Department of Pathology, AZ Klina, Brasschaat ††††††Department of Pathology, GZA Ziekenhuizen, Sint-Augustinus, Wilrijk ∥∥∥Molecular Immunology Unit ‡‡‡‡‡‡Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles ‡Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet **************European Organisation for Research and Treatment of Cancer (EORTC) Headquarters *******Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium §§§§§§§Department of Surgery, Kansai Medical School, Hirakata, Japan #######Severance Biomedical Science Institute and Department of Medical Oncology, Yonsei University College of Medicine, Seoul, South Korea ∥∥∥∥∥∥∥∥Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center ¶¶¶¶¶¶¶¶Institute of Oncology, Gliwice Branch, Gliwice, Poland ‡‡‡‡‡‡‡‡‡‡‡‡‡‡Pathology and Tissue Analytics, Roche Innovation Centre Munich, Penzberg †††††††††Institute of Pathology, Charité Universitätsmedizin Berlin ‡‡‡‡‡‡‡‡‡VMscope GmbH, Berlin ¶¶¶¶¶¶¶¶¶German Breast Group GmbH, Neu-Isenburg, Germany **********Trev & Joyce Deeley Research Centre, British Columbia Cancer Agency ††††††††††Department of Biochemistry and Microbiology, University of Victoria, Victoria Departments of ‡‡‡‡‡‡‡‡‡‡Medical Genetics #########Pathology and Laboratory Medicine ¶¶¶¶¶¶¶¶¶¶¶Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC ###########Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada §§§§§§§§§§§Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Doha, Qatar ‡‡‡‡‡‡‡‡Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center §§§§§§§§Warren Alpert Medical School of Brown University, Providence ¶¶¶¶¶National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, PA †††Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Departments of ‡‡‡Pathology, Microbiology and Immunology ########Department of Medicine, Vanderbilt University Medical Centre *********Vanderbilt Ingram Cancer Center, Nashville §§§§§§§§§Department of Pathology, Yale University School of Medicine, New Haven ∥∥∥∥∥∥∥∥∥∥∥Department of Oncology, Montefiore Medical Centre, Albert Einstein College of Medicine ∥∥∥∥∥∥∥Montefiore Medical Center ¶¶¶¶¶¶¶The Albert Einstein College of Medicine, Bronx, NY ********Department of Pathology, Brigham and Women's Hospital #####Cancer Research Institute and Department of Pathology, Beth Israel Deaconess Cancer Center ******Harvard Medical School ¶¶¶¶¶¶¶¶¶¶¶¶Division of Hematology-Oncology, Beth Israel Deaconess Medical Center ††††††††Department of Cancer Biology ‡‡‡‡‡‡‡‡‡‡‡‡‡Dana-Farber Cancer Institute, Boston, MA ∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO ‡‡‡‡‡Department of Cancer Biology, Mayo Clinic, Jacksonville, FL ∥∥∥∥∥∥Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN ¶¶¶¶¶¶Cancer Immunotherapy Trials Network, Central Laboratory and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA ††††††††††††Department of Pathology, New York University Langone Medical Centre ############New York University Medical School *************Perlmutter Cancer Center §§§§§§§§§§§§§Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University ***************Department of Pathology, Memorial Sloan-Kettering Cancer Center ####Departments of Radiation Oncology and Pathology, Weill Cornell Medicine, New York, NY *****Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX ∥∥∥∥∥∥∥∥∥∥∥∥Pathology Department, Stanford University Medical Centre, Stanford ∥∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Pathology, Stanford University, Palo Alto ***Department of Pathology, School of Medicine, University of California, San Diego §§§§§§§§§§§§§§Research Pathology, Genentech Inc., South San Francisco, CA *************Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda ¶¶¶¶¶¶¶¶¶¶¶¶¶¶Translational Sciences, MedImmune, Gaithersberg, MD §§§§§§Academic Medical Innovation, Novartis Pharmaceuticals Corporation, East Hanover ##############Translational Medicine, Merck & Co. Inc., Kenilworth, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Departments of *Pathology §§§Medical Oncology, Peter MacCallum Cancer Centre, Melbourne †The Sir Peter MacCallum Department of Oncology Departments of **Pathology ∥∥Medicine, University of Melbourne ¶¶Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville #Department of Anatomical Pathology, St Vincent's Hospital Melbourne, Fitzroy ††Department of Medical Oncology, Austin Health ‡‡Olivia Newton-John Cancer Research Institute, Heidelberg §§School of Cancer Medicine, La Trobe University, Bundoora §§§§§Centre for Clinical Research and School of Medicine, The University of Queensland ∥∥∥∥∥Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane §§§§§§§§§§The Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst ∥∥∥∥∥∥∥∥∥∥Australian Clinical Labs, Bella Vista ‡‡‡‡‡‡‡‡‡‡‡‡Directorate of Surgical Pathology, SA Pathology §§§§§§§§§§§§Discipline of Medicine, Adelaide University, Adelaide, Australia ***********Department of Surgical Oncology, Netherlands Cancer Institute †††††††††††††Department of Pathology ##Divisions of Diagnostic Oncology & Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands ###Université Paris-Est ****INSERM, UMR 955 ††††Département de pathologie, APHP, Hôpital Henri-Mondor, Créteil ∥∥∥∥∥∥∥∥∥Service de Biostatistique et d'Epidémiologie, Gustave Roussy, CESP, Inserm U1018, Université-Paris Sud, Université Paris-Saclay ¶¶¶¶¶¶¶¶¶¶INSERM Unit U981, and Department of Medical Oncology, Gustave Roussy, Villejuif ##########Faculté de Médecine, Université Paris Sud, Kremlin-Bicêtre †††††††Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre ‡‡‡‡‡‡‡University of Auvergne UMR1240, Clermont-Ferrand, France ‡‡‡‡Department of Medicine, Clinical Division of Oncology §§§§Institute of Neurology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Vienna ††††††††††††††Institute of Pathology, Medical University of Graz, Austria ∥∥∥∥European Institute of Oncology ¶¶¶¶School of Medicine ######Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan ¶¶¶¶¶¶¶¶¶¶¶¶¶Department of Surgery, Oncology and Gastroenterology, University of Padova #############Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy †††††Molecular Oncology Group, Vall d'Hebron Institute of Oncology, Barcelona †††††††††††Pathology Department, IIS-Fundacion Jimenez Diaz, UAM, Madrid, Spain §Department of Pathology and TCRU, GZA ¶¶¶Department of Pathology, GZA Ziekenhuizen, Antwerp ∥Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven ‡‡‡‡‡‡‡‡‡‡‡Department of Pathology, University Hospital Leuven, Leuven, Belgium ¶Department of Pathology, AZ Klina, Brasschaat ††††††Department of Pathology, GZA Ziekenhuizen, Sint-Augustinus, Wilrijk ∥∥∥Molecular Immunology Unit ‡‡‡‡‡‡Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles ‡Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet **************European Organisation for Research and Treatment of Cancer (EORTC) Headquarters *******Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium §§§§§§§Department of Surgery, Kansai Medical School, Hirakata, Japan #######Severance Biomedical Science Institute and Department of Medical Oncology, Yonsei University College of Medicine, Seoul, South Korea ∥∥∥∥∥∥∥∥Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center ¶¶¶¶¶¶¶¶Institute of Oncology, Gliwice Branch, Gliwice, Poland ‡‡‡‡‡‡‡‡‡‡‡‡‡‡Pathology and Tissue Analytics, Roche Innovation Centre Munich, Penzberg †††††††††Institute of Pathology, Charité Universitätsmedizin Berlin ‡‡‡‡‡‡‡‡‡VMscope GmbH, Berlin ¶¶¶¶¶¶¶¶¶German Breast Group GmbH, Neu-Isenburg, Germany **********Trev & Joyce Deeley Research Centre, British Columbia Cancer Agency ††††††††††Department of Biochemistry and Microbiology, University of Victoria, Victoria Departments of ‡‡‡‡‡‡‡‡‡‡Medical Genetics #########Pathology and Laboratory Medicine ¶¶¶¶¶¶¶¶¶¶¶Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC ###########Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada §§§§§§§§§§§Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Doha, Qatar ‡‡‡‡‡‡‡‡Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center §§§§§§§§Warren Alpert Medical School of Brown University, Providence ¶¶¶¶¶National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, PA †††Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Departments of ‡‡‡Pathology, Microbiology and Immunology ########Department of Medicine, Vanderbilt University Medical Centre *********Vanderbilt Ingram Cancer Center, Nashville §§§§§§§§§Department of Pathology, Yale University School of Medicine, New Haven ∥∥∥∥∥∥∥∥∥∥∥Department of Oncology, Montefiore Medical Centre, Albert Einstein College of Medicine ∥∥∥∥∥∥∥Montefiore Medical Center ¶¶¶¶¶¶¶The Albert Einstein College of Medicine, Bronx, NY ********Department of Pathology, Brigham and Women's Hospital #####Cancer Research Institute and Department of Pathology, Beth Israel Deaconess Cancer Center ******Harvard Medical School ¶¶¶¶¶¶¶¶¶¶¶¶Division of Hematology-Oncology, Beth Israel Deaconess Medical Center ††††††††Department of Cancer Biology ‡‡‡‡‡‡‡‡‡‡‡‡‡Dana-Farber Cancer Institute, Boston, MA ∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO ‡‡‡‡‡Department of Cancer Biology, Mayo Clinic, Jacksonville, FL ∥∥∥∥∥∥Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN ¶¶¶¶¶¶Cancer Immunotherapy Trials Network, Central Laboratory and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA ††††††††††††Department of Pathology, New York University Langone Medical Centre ############New York University Medical School *************Perlmutter Cancer Center §§§§§§§§§§§§§Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University ***************Department of Pathology, Memorial Sloan-Kettering Cancer Center ####Departments of Radiation Oncology and Pathology, Weill Cornell Medicine, New York, NY *****Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX ∥∥∥∥∥∥∥∥∥∥∥∥Pathology Department, Stanford University Medical Centre, Stanford ∥∥∥∥∥∥∥∥∥∥∥∥∥∥Department of Pathology, Stanford University, Palo Alto ***Department of Pathology, School of Medicine, University of California, San Diego §§§§§§§§§§§§§§Research Pathology, Genentech Inc., South San Francisco, CA *************Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda ¶¶¶¶¶¶¶¶¶¶¶¶¶¶Translational Sciences, MedImmune, Gaithersberg, MD §§§§§§Academic Medical Innovation, Novartis Pharmaceuticals Corporation, East Hanover ##############Translational Medicine, Merck & Co. Inc., Kenilworth</wicri:cityArea></affiliation></author><author><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name></author><author><name sortKey="Gevaert, Thomas" sort="Gevaert, Thomas" uniqKey="Gevaert T" first="Thomas" last="Gevaert">Thomas Gevaert</name></author><author><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name></author><author><name sortKey="John, Tom" sort="John, Tom" uniqKey="John T" first="Tom" last="John">Tom John</name></author><author><name sortKey="Thapa, Bibhusal" sort="Thapa, Bibhusal" uniqKey="Thapa B" first="Bibhusal" last="Thapa">Bibhusal Thapa</name></author><author><name sortKey="Christie, Michael" sort="Christie, Michael" uniqKey="Christie M" first="Michael" last="Christie">Michael Christie</name></author><author><name sortKey="Van De Vijver, Koen" sort="Van De Vijver, Koen" uniqKey="Van De Vijver K" first="Koen" last="Van De Vijver">Koen Van De Vijver</name></author><author><name sortKey="Estrada, M V" sort="Estrada, M V" uniqKey="Estrada M" first="M V" last="Estrada">M V Estrada</name></author><author><name sortKey="Gonzalez Ericsson, Paula I" sort="Gonzalez Ericsson, Paula I" uniqKey="Gonzalez Ericsson P" first="Paula I" last="Gonzalez-Ericsson">Paula I. Gonzalez-Ericsson</name></author><author><name sortKey="Sanders, Melinda" sort="Sanders, Melinda" uniqKey="Sanders M" first="Melinda" last="Sanders">Melinda Sanders</name></author><author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name></author><author><name sortKey="Solinas, Cinzia" sort="Solinas, Cinzia" uniqKey="Solinas C" first="Cinzia" last="Solinas">Cinzia Solinas</name></author><author><name sortKey="Van Den Eynden, Gert G G M" sort="Van Den Eynden, Gert G G M" uniqKey="Van Den Eynden G" first="Gert G G M" last="Van Den Eynden">Gert G G M. Van Den Eynden</name></author><author><name sortKey="Allory, Yves" sort="Allory, Yves" uniqKey="Allory Y" first="Yves" last="Allory">Yves Allory</name></author><author><name sortKey="Preusser, Matthias" sort="Preusser, Matthias" uniqKey="Preusser M" first="Matthias" last="Preusser">Matthias Preusser</name></author><author><name sortKey="Hainfellner, Johannes" sort="Hainfellner, Johannes" uniqKey="Hainfellner J" first="Johannes" last="Hainfellner">Johannes Hainfellner</name></author><author><name sortKey="Pruneri, Giancarlo" sort="Pruneri, Giancarlo" uniqKey="Pruneri G" first="Giancarlo" last="Pruneri">Giancarlo Pruneri</name></author><author><name sortKey="Vingiani, Andrea" sort="Vingiani, Andrea" uniqKey="Vingiani A" first="Andrea" last="Vingiani">Andrea Vingiani</name></author><author><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name></author><author><name sortKey="Symmans, Fraser" sort="Symmans, Fraser" uniqKey="Symmans F" first="Fraser" last="Symmans">Fraser Symmans</name></author><author><name sortKey="Nuciforo, Paolo" sort="Nuciforo, Paolo" uniqKey="Nuciforo P" first="Paolo" last="Nuciforo">Paolo Nuciforo</name></author><author><name sortKey="Comerma, Laura" sort="Comerma, Laura" uniqKey="Comerma L" first="Laura" last="Comerma">Laura Comerma</name></author><author><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name></author><author><name sortKey="Lakhani, Sunil" sort="Lakhani, Sunil" uniqKey="Lakhani S" first="Sunil" last="Lakhani">Sunil Lakhani</name></author><author><name sortKey="Kim, Seong Rim" sort="Kim, Seong Rim" uniqKey="Kim S" first="Seong-Rim" last="Kim">Seong-Rim Kim</name></author><author><name sortKey="Schnitt, Stuart" sort="Schnitt, Stuart" uniqKey="Schnitt S" first="Stuart" last="Schnitt">Stuart Schnitt</name></author><author><name sortKey="Colpaert, Cecile" sort="Colpaert, Cecile" uniqKey="Colpaert C" first="Cecile" last="Colpaert">Cecile Colpaert</name></author><author><name sortKey="Sotiriou, Christos" sort="Sotiriou, Christos" uniqKey="Sotiriou C" first="Christos" last="Sotiriou">Christos Sotiriou</name></author><author><name sortKey="Scherer, Stefan J" sort="Scherer, Stefan J" uniqKey="Scherer S" first="Stefan J" last="Scherer">Stefan J. Scherer</name></author><author><name sortKey="Ignatiadis, Michail" sort="Ignatiadis, Michail" uniqKey="Ignatiadis M" first="Michail" last="Ignatiadis">Michail Ignatiadis</name></author><author><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name></author><author><name sortKey="Pierce, Robert H" sort="Pierce, Robert H" uniqKey="Pierce R" first="Robert H" last="Pierce">Robert H. Pierce</name></author><author><name sortKey="Viale, Giuseppe" sort="Viale, Giuseppe" uniqKey="Viale G" first="Giuseppe" last="Viale">Giuseppe Viale</name></author><author><name sortKey="Sirtaine, Nicolas" sort="Sirtaine, Nicolas" uniqKey="Sirtaine N" first="Nicolas" last="Sirtaine">Nicolas Sirtaine</name></author><author><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name></author><author><name sortKey="Sugie, Tomohagu" sort="Sugie, Tomohagu" uniqKey="Sugie T" first="Tomohagu" last="Sugie">Tomohagu Sugie</name></author><author><name sortKey="Fineberg, Susan" sort="Fineberg, Susan" uniqKey="Fineberg S" first="Susan" last="Fineberg">Susan Fineberg</name></author><author><name sortKey="Paik, Soonmyung" sort="Paik, Soonmyung" uniqKey="Paik S" first="Soonmyung" last="Paik">Soonmyung Paik</name></author><author><name sortKey="Srinivasan, Ashok" sort="Srinivasan, Ashok" uniqKey="Srinivasan A" first="Ashok" last="Srinivasan">Ashok Srinivasan</name></author><author><name sortKey="Richardson, Andrea" sort="Richardson, Andrea" uniqKey="Richardson A" first="Andrea" last="Richardson">Andrea Richardson</name></author><author><name sortKey="Wang, Yihong" sort="Wang, Yihong" uniqKey="Wang Y" first="Yihong" last="Wang">Yihong Wang</name></author><author><name sortKey="Chmielik, Ewa" sort="Chmielik, Ewa" uniqKey="Chmielik E" first="Ewa" last="Chmielik">Ewa Chmielik</name></author><author><name sortKey="Brock, Jane" sort="Brock, Jane" uniqKey="Brock J" first="Jane" last="Brock">Jane Brock</name></author><author><name sortKey="Johnson, Douglas B" sort="Johnson, Douglas B" uniqKey="Johnson D" first="Douglas B" last="Johnson">Douglas B. Johnson</name></author><author><name sortKey="Balko, Justin" sort="Balko, Justin" uniqKey="Balko J" first="Justin" last="Balko">Justin Balko</name></author><author><name sortKey="Wienert, Stephan" sort="Wienert, Stephan" uniqKey="Wienert S" first="Stephan" last="Wienert">Stephan Wienert</name></author><author><name sortKey="Bossuyt, Veerle" sort="Bossuyt, Veerle" uniqKey="Bossuyt V" first="Veerle" last="Bossuyt">Veerle Bossuyt</name></author><author><name sortKey="Michiels, Stefan" sort="Michiels, Stefan" uniqKey="Michiels S" first="Stefan" last="Michiels">Stefan Michiels</name></author><author><name sortKey="Ternes, Nils" sort="Ternes, Nils" uniqKey="Ternes N" first="Nils" last="Ternes">Nils Ternes</name></author><author><name sortKey="Burchardi, Nicole" sort="Burchardi, Nicole" uniqKey="Burchardi N" first="Nicole" last="Burchardi">Nicole Burchardi</name></author><author><name sortKey="Luen, Stephen J" sort="Luen, Stephen J" uniqKey="Luen S" first="Stephen J" last="Luen">Stephen J. Luen</name></author><author><name sortKey="Savas, Peter" sort="Savas, Peter" uniqKey="Savas P" first="Peter" last="Savas">Peter Savas</name></author><author><name sortKey="Klauschen, Frederick" sort="Klauschen, Frederick" uniqKey="Klauschen F" first="Frederick" last="Klauschen">Frederick Klauschen</name></author><author><name sortKey="Watson, Peter H" sort="Watson, Peter H" uniqKey="Watson P" first="Peter H" last="Watson">Peter H. Watson</name></author><author><name sortKey="Nelson, Brad H" sort="Nelson, Brad H" uniqKey="Nelson B" first="Brad H" last="Nelson">Brad H. Nelson</name></author><author><name sortKey="Criscitiello, Carmen" sort="Criscitiello, Carmen" uniqKey="Criscitiello C" first="Carmen" last="Criscitiello">Carmen Criscitiello</name></author><author><name sortKey="O Toole, Sandra" sort="O Toole, Sandra" uniqKey="O Toole S" first="Sandra" last="O'Toole">Sandra O'Toole</name></author><author><name sortKey="Larsimont, Denis" sort="Larsimont, Denis" uniqKey="Larsimont D" first="Denis" last="Larsimont">Denis Larsimont</name></author><author><name sortKey="De Wind, Roland" sort="De Wind, Roland" uniqKey="De Wind R" first="Roland" last="De Wind">Roland De Wind</name></author><author><name sortKey="Curigliano, Giuseppe" sort="Curigliano, Giuseppe" uniqKey="Curigliano G" first="Giuseppe" last="Curigliano">Giuseppe Curigliano</name></author><author><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="André">Fabrice André</name></author><author><name sortKey="Lacroix Triki, Magali" sort="Lacroix Triki, Magali" uniqKey="Lacroix Triki M" first="Magali" last="Lacroix-Triki">Magali Lacroix-Triki</name></author><author><name sortKey="Van De Vijver, Mark" sort="Van De Vijver, Mark" uniqKey="Van De Vijver M" first="Mark" last="Van De Vijver">Mark Van De Vijver</name></author><author><name sortKey="Rojo, Federico" sort="Rojo, Federico" uniqKey="Rojo F" first="Federico" last="Rojo">Federico Rojo</name></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name></author><author><name sortKey="Bedri, Shahinaz" sort="Bedri, Shahinaz" uniqKey="Bedri S" first="Shahinaz" last="Bedri">Shahinaz Bedri</name></author><author><name sortKey="Sparano, Joseph" sort="Sparano, Joseph" uniqKey="Sparano J" first="Joseph" last="Sparano">Joseph Sparano</name></author><author><name sortKey="Rimm, David" sort="Rimm, David" uniqKey="Rimm D" first="David" last="Rimm">David Rimm</name></author><author><name sortKey="Nielsen, Torsten" sort="Nielsen, Torsten" uniqKey="Nielsen T" first="Torsten" last="Nielsen">Torsten Nielsen</name></author><author><name sortKey="Kos, Zuzana" sort="Kos, Zuzana" uniqKey="Kos Z" first="Zuzana" last="Kos">Zuzana Kos</name></author><author><name sortKey="Hewitt, Stephen" sort="Hewitt, Stephen" uniqKey="Hewitt S" first="Stephen" last="Hewitt">Stephen Hewitt</name></author><author><name sortKey="Singh, Baljit" sort="Singh, Baljit" uniqKey="Singh B" first="Baljit" last="Singh">Baljit Singh</name></author><author><name sortKey="Farshid, Gelareh" sort="Farshid, Gelareh" uniqKey="Farshid G" first="Gelareh" last="Farshid">Gelareh Farshid</name></author><author><name sortKey="Loibl, Sibylle" sort="Loibl, Sibylle" uniqKey="Loibl S" first="Sibylle" last="Loibl">Sibylle Loibl</name></author><author><name sortKey="Allison, Kimberly H" sort="Allison, Kimberly H" uniqKey="Allison K" first="Kimberly H" last="Allison">Kimberly H. Allison</name></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name></author><author><name sortKey="Adams, Sylvia" sort="Adams, Sylvia" uniqKey="Adams S" first="Sylvia" last="Adams">Sylvia Adams</name></author><author><name sortKey="Willard Gallo, Karen" sort="Willard Gallo, Karen" uniqKey="Willard Gallo K" first="Karen" last="Willard-Gallo">Karen Willard-Gallo</name></author><author><name sortKey="Horlings, Hugo M" sort="Horlings, Hugo M" uniqKey="Horlings H" first="Hugo M" last="Horlings">Hugo M. Horlings</name></author><author><name sortKey="Gandhi, Leena" sort="Gandhi, Leena" uniqKey="Gandhi L" first="Leena" last="Gandhi">Leena Gandhi</name></author><author><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name></author><author><name sortKey="Hirsch, Fred" sort="Hirsch, Fred" uniqKey="Hirsch F" first="Fred" last="Hirsch">Fred Hirsch</name></author><author><name sortKey="Dieci, Maria V" sort="Dieci, Maria V" uniqKey="Dieci M" first="Maria V" last="Dieci">Maria V. Dieci</name></author><author><name sortKey="Urbanowicz, Maria" sort="Urbanowicz, Maria" uniqKey="Urbanowicz M" first="Maria" last="Urbanowicz">Maria Urbanowicz</name></author><author><name sortKey="Brcic, Iva" sort="Brcic, Iva" uniqKey="Brcic I" first="Iva" last="Brcic">Iva Brcic</name></author><author><name sortKey="Korski, Konstanty" sort="Korski, Konstanty" uniqKey="Korski K" first="Konstanty" last="Korski">Konstanty Korski</name></author><author><name sortKey="Gaire, Fabien" sort="Gaire, Fabien" uniqKey="Gaire F" first="Fabien" last="Gaire">Fabien Gaire</name></author><author><name sortKey="Koeppen, Hartmut" sort="Koeppen, Hartmut" uniqKey="Koeppen H" first="Hartmut" last="Koeppen">Hartmut Koeppen</name></author><author><name sortKey="Lo, Amy" sort="Lo, Amy" uniqKey="Lo A" first="Amy" last="Lo">Amy Lo</name></author><author><name sortKey="Giltnane, Jennifer" sort="Giltnane, Jennifer" uniqKey="Giltnane J" first="Jennifer" last="Giltnane">Jennifer Giltnane</name></author><author><name sortKey="Rebelatto, Marlon C" sort="Rebelatto, Marlon C" uniqKey="Rebelatto M" first="Marlon C" last="Rebelatto">Marlon C. Rebelatto</name></author><author><name sortKey="Steele, Keith E" sort="Steele, Keith E" uniqKey="Steele K" first="Keith E" last="Steele">Keith E. Steele</name></author><author><name sortKey="Zha, Jiping" sort="Zha, Jiping" uniqKey="Zha J" first="Jiping" last="Zha">Jiping Zha</name></author><author><name sortKey="Emancipator, Kenneth" sort="Emancipator, Kenneth" uniqKey="Emancipator K" first="Kenneth" last="Emancipator">Kenneth Emancipator</name></author><author><name sortKey="Juco, Jonathan W" sort="Juco, Jonathan W" uniqKey="Juco J" first="Jonathan W" last="Juco">Jonathan W. Juco</name></author><author><name sortKey="Denkert, Carsten" sort="Denkert, Carsten" uniqKey="Denkert C" first="Carsten" last="Denkert">Carsten Denkert</name></author><author><name sortKey="Reis Filho, Jorge" sort="Reis Filho, Jorge" uniqKey="Reis Filho J" first="Jorge" last="Reis-Filho">Jorge Reis-Filho</name></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name></author><author><name sortKey="Fox, Stephen B" sort="Fox, Stephen B" uniqKey="Fox S" first="Stephen B" last="Fox">Stephen B. Fox</name></author></analytic><series><title level="j">Advances in anatomic pathology</title><idno type="eISSN">1533-4031</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li></region></list><tree><noCountry><name sortKey="Adams, Sylvia" sort="Adams, Sylvia" uniqKey="Adams S" first="Sylvia" last="Adams">Sylvia Adams</name><name sortKey="Allison, Kimberly H" sort="Allison, Kimberly H" uniqKey="Allison K" first="Kimberly H" last="Allison">Kimberly H. Allison</name><name sortKey="Allory, Yves" sort="Allory, Yves" uniqKey="Allory Y" first="Yves" last="Allory">Yves Allory</name><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="André">Fabrice André</name><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name><name sortKey="Balko, Justin" sort="Balko, Justin" uniqKey="Balko J" first="Justin" last="Balko">Justin Balko</name><name sortKey="Bedri, Shahinaz" sort="Bedri, Shahinaz" uniqKey="Bedri S" first="Shahinaz" last="Bedri">Shahinaz Bedri</name><name sortKey="Bossuyt, Veerle" sort="Bossuyt, Veerle" uniqKey="Bossuyt V" first="Veerle" last="Bossuyt">Veerle Bossuyt</name><name sortKey="Brcic, Iva" sort="Brcic, Iva" uniqKey="Brcic I" first="Iva" last="Brcic">Iva Brcic</name><name sortKey="Brock, Jane" sort="Brock, Jane" uniqKey="Brock J" first="Jane" last="Brock">Jane Brock</name><name sortKey="Burchardi, Nicole" sort="Burchardi, Nicole" uniqKey="Burchardi N" first="Nicole" last="Burchardi">Nicole Burchardi</name><name sortKey="Chmielik, Ewa" sort="Chmielik, Ewa" uniqKey="Chmielik E" first="Ewa" last="Chmielik">Ewa Chmielik</name><name sortKey="Christie, Michael" sort="Christie, Michael" uniqKey="Christie M" first="Michael" last="Christie">Michael Christie</name><name sortKey="Colpaert, Cecile" sort="Colpaert, Cecile" uniqKey="Colpaert C" first="Cecile" last="Colpaert">Cecile Colpaert</name><name sortKey="Comerma, Laura" sort="Comerma, Laura" uniqKey="Comerma L" first="Laura" last="Comerma">Laura Comerma</name><name sortKey="Criscitiello, Carmen" sort="Criscitiello, Carmen" uniqKey="Criscitiello C" first="Carmen" last="Criscitiello">Carmen Criscitiello</name><name sortKey="Curigliano, Giuseppe" sort="Curigliano, Giuseppe" uniqKey="Curigliano G" first="Giuseppe" last="Curigliano">Giuseppe Curigliano</name><name sortKey="De Wind, Roland" sort="De Wind, Roland" uniqKey="De Wind R" first="Roland" last="De Wind">Roland De Wind</name><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name><name sortKey="Denkert, Carsten" sort="Denkert, Carsten" uniqKey="Denkert C" first="Carsten" last="Denkert">Carsten Denkert</name><name sortKey="Dieci, Maria V" sort="Dieci, Maria V" uniqKey="Dieci M" first="Maria V" last="Dieci">Maria V. Dieci</name><name sortKey="Emancipator, Kenneth" sort="Emancipator, Kenneth" uniqKey="Emancipator K" first="Kenneth" last="Emancipator">Kenneth Emancipator</name><name sortKey="Estrada, M V" sort="Estrada, M V" uniqKey="Estrada M" first="M V" last="Estrada">M V Estrada</name><name sortKey="Farshid, Gelareh" sort="Farshid, Gelareh" uniqKey="Farshid G" first="Gelareh" last="Farshid">Gelareh Farshid</name><name sortKey="Fineberg, Susan" sort="Fineberg, Susan" uniqKey="Fineberg S" first="Susan" last="Fineberg">Susan Fineberg</name><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><name sortKey="Fox, Stephen B" sort="Fox, Stephen B" uniqKey="Fox S" first="Stephen B" last="Fox">Stephen B. Fox</name><name sortKey="Gaire, Fabien" sort="Gaire, Fabien" uniqKey="Gaire F" first="Fabien" last="Gaire">Fabien Gaire</name><name sortKey="Gandhi, Leena" sort="Gandhi, Leena" uniqKey="Gandhi L" first="Leena" last="Gandhi">Leena Gandhi</name><name sortKey="Gevaert, Thomas" sort="Gevaert, Thomas" uniqKey="Gevaert T" first="Thomas" last="Gevaert">Thomas Gevaert</name><name sortKey="Giltnane, Jennifer" sort="Giltnane, Jennifer" uniqKey="Giltnane J" first="Jennifer" last="Giltnane">Jennifer Giltnane</name><name sortKey="Gonzalez Ericsson, Paula I" sort="Gonzalez Ericsson, Paula I" uniqKey="Gonzalez Ericsson P" first="Paula I" last="Gonzalez-Ericsson">Paula I. Gonzalez-Ericsson</name><name sortKey="Hainfellner, Johannes" sort="Hainfellner, Johannes" uniqKey="Hainfellner J" first="Johannes" last="Hainfellner">Johannes Hainfellner</name><name sortKey="Hewitt, Stephen" sort="Hewitt, Stephen" uniqKey="Hewitt S" first="Stephen" last="Hewitt">Stephen Hewitt</name><name sortKey="Hirsch, Fred" sort="Hirsch, Fred" uniqKey="Hirsch F" first="Fred" last="Hirsch">Fred Hirsch</name><name sortKey="Horlings, Hugo M" sort="Horlings, Hugo M" uniqKey="Horlings H" first="Hugo M" last="Horlings">Hugo M. Horlings</name><name sortKey="Ignatiadis, Michail" sort="Ignatiadis, Michail" uniqKey="Ignatiadis M" first="Michail" last="Ignatiadis">Michail Ignatiadis</name><name sortKey="John, Tom" sort="John, Tom" uniqKey="John T" first="Tom" last="John">Tom John</name><name sortKey="Johnson, Douglas B" sort="Johnson, Douglas B" uniqKey="Johnson D" first="Douglas B" last="Johnson">Douglas B. Johnson</name><name sortKey="Juco, Jonathan W" sort="Juco, Jonathan W" uniqKey="Juco J" first="Jonathan W" last="Juco">Jonathan W. Juco</name><name sortKey="Kim, Seong Rim" sort="Kim, Seong Rim" uniqKey="Kim S" first="Seong-Rim" last="Kim">Seong-Rim Kim</name><name sortKey="Klauschen, Frederick" sort="Klauschen, Frederick" uniqKey="Klauschen F" first="Frederick" last="Klauschen">Frederick Klauschen</name><name sortKey="Koeppen, Hartmut" sort="Koeppen, Hartmut" uniqKey="Koeppen H" first="Hartmut" last="Koeppen">Hartmut Koeppen</name><name sortKey="Korski, Konstanty" sort="Korski, Konstanty" uniqKey="Korski K" first="Konstanty" last="Korski">Konstanty Korski</name><name sortKey="Kos, Zuzana" sort="Kos, Zuzana" uniqKey="Kos Z" first="Zuzana" last="Kos">Zuzana Kos</name><name sortKey="Lacroix Triki, Magali" sort="Lacroix Triki, Magali" uniqKey="Lacroix Triki M" first="Magali" last="Lacroix-Triki">Magali Lacroix-Triki</name><name sortKey="Lakhani, Sunil" sort="Lakhani, Sunil" uniqKey="Lakhani S" first="Sunil" last="Lakhani">Sunil Lakhani</name><name sortKey="Larsimont, Denis" sort="Larsimont, Denis" uniqKey="Larsimont D" first="Denis" last="Larsimont">Denis Larsimont</name><name sortKey="Lo, Amy" sort="Lo, Amy" uniqKey="Lo A" first="Amy" last="Lo">Amy Lo</name><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name><name sortKey="Loibl, Sibylle" sort="Loibl, Sibylle" uniqKey="Loibl S" first="Sibylle" last="Loibl">Sibylle Loibl</name><name sortKey="Luen, Stephen J" sort="Luen, Stephen J" uniqKey="Luen S" first="Stephen J" last="Luen">Stephen J. Luen</name><name sortKey="Michiels, Stefan" sort="Michiels, Stefan" uniqKey="Michiels S" first="Stefan" last="Michiels">Stefan Michiels</name><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name><name sortKey="Nelson, Brad H" sort="Nelson, Brad H" uniqKey="Nelson B" first="Brad H" last="Nelson">Brad H. Nelson</name><name sortKey="Nielsen, Torsten" sort="Nielsen, Torsten" uniqKey="Nielsen T" first="Torsten" last="Nielsen">Torsten Nielsen</name><name sortKey="Nuciforo, Paolo" sort="Nuciforo, Paolo" uniqKey="Nuciforo P" first="Paolo" last="Nuciforo">Paolo Nuciforo</name><name sortKey="O Toole, Sandra" sort="O Toole, Sandra" uniqKey="O Toole S" first="Sandra" last="O'Toole">Sandra O'Toole</name><name sortKey="Paik, Soonmyung" sort="Paik, Soonmyung" uniqKey="Paik S" first="Soonmyung" last="Paik">Soonmyung Paik</name><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name><name sortKey="Pierce, Robert H" sort="Pierce, Robert H" uniqKey="Pierce R" first="Robert H" last="Pierce">Robert H. Pierce</name><name sortKey="Preusser, Matthias" sort="Preusser, Matthias" uniqKey="Preusser M" first="Matthias" last="Preusser">Matthias Preusser</name><name sortKey="Pruneri, Giancarlo" sort="Pruneri, Giancarlo" uniqKey="Pruneri G" first="Giancarlo" last="Pruneri">Giancarlo Pruneri</name><name sortKey="Rebelatto, Marlon C" sort="Rebelatto, Marlon C" uniqKey="Rebelatto M" first="Marlon C" last="Rebelatto">Marlon C. Rebelatto</name><name sortKey="Reis Filho, Jorge" sort="Reis Filho, Jorge" uniqKey="Reis Filho J" first="Jorge" last="Reis-Filho">Jorge Reis-Filho</name><name sortKey="Richardson, Andrea" sort="Richardson, Andrea" uniqKey="Richardson A" first="Andrea" last="Richardson">Andrea Richardson</name><name sortKey="Rimm, David" sort="Rimm, David" uniqKey="Rimm D" first="David" last="Rimm">David Rimm</name><name sortKey="Rojo, Federico" sort="Rojo, Federico" uniqKey="Rojo F" first="Federico" last="Rojo">Federico Rojo</name><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name><name sortKey="Sanders, Melinda" sort="Sanders, Melinda" uniqKey="Sanders M" first="Melinda" last="Sanders">Melinda Sanders</name><name sortKey="Savas, Peter" sort="Savas, Peter" uniqKey="Savas P" first="Peter" last="Savas">Peter Savas</name><name sortKey="Scherer, Stefan J" sort="Scherer, Stefan J" uniqKey="Scherer S" first="Stefan J" last="Scherer">Stefan J. Scherer</name><name sortKey="Schnitt, Stuart" sort="Schnitt, Stuart" uniqKey="Schnitt S" first="Stuart" last="Schnitt">Stuart Schnitt</name><name sortKey="Singh, Baljit" sort="Singh, Baljit" uniqKey="Singh B" first="Baljit" last="Singh">Baljit Singh</name><name sortKey="Sirtaine, Nicolas" sort="Sirtaine, Nicolas" uniqKey="Sirtaine N" first="Nicolas" last="Sirtaine">Nicolas Sirtaine</name><name sortKey="Solinas, Cinzia" sort="Solinas, Cinzia" uniqKey="Solinas C" first="Cinzia" last="Solinas">Cinzia Solinas</name><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name><name sortKey="Sotiriou, Christos" sort="Sotiriou, Christos" uniqKey="Sotiriou C" first="Christos" last="Sotiriou">Christos Sotiriou</name><name sortKey="Sparano, Joseph" sort="Sparano, Joseph" uniqKey="Sparano J" first="Joseph" last="Sparano">Joseph Sparano</name><name sortKey="Srinivasan, Ashok" sort="Srinivasan, Ashok" uniqKey="Srinivasan A" first="Ashok" last="Srinivasan">Ashok Srinivasan</name><name sortKey="Steele, Keith E" sort="Steele, Keith E" uniqKey="Steele K" first="Keith E" last="Steele">Keith E. Steele</name><name sortKey="Sugie, Tomohagu" sort="Sugie, Tomohagu" uniqKey="Sugie T" first="Tomohagu" last="Sugie">Tomohagu Sugie</name><name sortKey="Symmans, Fraser" sort="Symmans, Fraser" uniqKey="Symmans F" first="Fraser" last="Symmans">Fraser Symmans</name><name sortKey="Ternes, Nils" sort="Ternes, Nils" uniqKey="Ternes N" first="Nils" last="Ternes">Nils Ternes</name><name sortKey="Thapa, Bibhusal" sort="Thapa, Bibhusal" uniqKey="Thapa B" first="Bibhusal" last="Thapa">Bibhusal Thapa</name><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><name sortKey="Urbanowicz, Maria" sort="Urbanowicz, Maria" uniqKey="Urbanowicz M" first="Maria" last="Urbanowicz">Maria Urbanowicz</name><name sortKey="Van De Vijver, Koen" sort="Van De Vijver, Koen" uniqKey="Van De Vijver K" first="Koen" last="Van De Vijver">Koen Van De Vijver</name><name sortKey="Van De Vijver, Mark" sort="Van De Vijver, Mark" uniqKey="Van De Vijver M" first="Mark" last="Van De Vijver">Mark Van De Vijver</name><name sortKey="Van Den Eynden, Gert G G M" sort="Van Den Eynden, Gert G G M" uniqKey="Van Den Eynden G" first="Gert G G M" last="Van Den Eynden">Gert G G M. Van Den Eynden</name><name sortKey="Viale, Giuseppe" sort="Viale, Giuseppe" uniqKey="Viale G" first="Giuseppe" last="Viale">Giuseppe Viale</name><name sortKey="Vingiani, Andrea" sort="Vingiani, Andrea" uniqKey="Vingiani A" first="Andrea" last="Vingiani">Andrea Vingiani</name><name sortKey="Wang, Yihong" sort="Wang, Yihong" uniqKey="Wang Y" first="Yihong" last="Wang">Yihong Wang</name><name sortKey="Watson, Peter H" sort="Watson, Peter H" uniqKey="Watson P" first="Peter H" last="Watson">Peter H. Watson</name><name sortKey="Wienert, Stephan" sort="Wienert, Stephan" uniqKey="Wienert S" first="Stephan" last="Wienert">Stephan Wienert</name><name sortKey="Willard Gallo, Karen" sort="Willard Gallo, Karen" uniqKey="Willard Gallo K" first="Karen" last="Willard-Gallo">Karen Willard-Gallo</name><name sortKey="Zha, Jiping" sort="Zha, Jiping" uniqKey="Zha J" first="Jiping" last="Zha">Jiping Zha</name></noCountry><country name="États-Unis"><region name="New Jersey"><name sortKey="Hendry, Shona" sort="Hendry, Shona" uniqKey="Hendry S" first="Shona" last="Hendry">Shona Hendry</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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